Mitogen-activated protein kinase kinase kinase



Mitogen-activated protein kinase kinase kinase (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of MAPK and MAP2K which are activated by phosphorylation. MAP3K activates MAP2K. The images on the left and right correspond to one representative MAP3K structure, i.e. the human MAP3K5 (2clq).

MAP3K1
1uti - MAP3K1+GRB2-related adaptor protein 2 - mouse

MAP3K2
2cu1 - hMAP3K2 PB1 domain (mutant) - human - NMR

2o2v, 1p38 – hMAP3K2+hMAP3K5 - human

MAP3K3
2c60 – hMAP3K3 PHOX domain

2jrh - hMAP3K3 PB1 domain

2pph - hMAP3K3 PB1 domain - NMR

MAP3K5
2clq – hMAP3K5

MAP3K9
3dtc - hMAP3K9 (mutant) + inhibitor

MAP3K10
2rf0 - hMAP3K10 SH3 domain - NMR